Pregnancy after Intracytoplasmic Sperm Injection in Couples with Kartagener Syndrome: Two Clinical Cases.
Gravidez pós-ICSI em casais com Síndrome de Kartagener: A propósito de dois casos clínicos.
Miranda, C., Costa, S., Coelho, D.* & Dantas, S.*
*) Hospital Senhora da Oliveira, Guimarães, Portugal.
DATES
CITATION
Miranda, C., Costa, S., Coelho, D., & Dantas, S. (2021, September 24-25). Pregnancy after intracytoplasmic sperm injection in couples with Kartagener syndrome: two clinical cases [Paper presentation]. XXXVII Reproductive Studies Journeys, Lisbon, Portugal. https://academy-on.com/videos/mh-373-11539
SYNOPSIS
This communication presents two cases of Kartagener syndrome where pregnancy was achieved with ICSI. Spermatozoa selection was performed using different methods and high fertilization rates were achieved in both cases. Our work highlights the importance of evaluation of spermatozoa by an experienced embryologist as one of the crucial steps in the management of these couples.
Esta comunicação apresenta dois casos de Síndrome de Kartagener em que a gravidez foi obtida com ICSI. A seleção de espermatozoides foi realizada usando diferentes técnicas, tendo-se obtido elevadas taxas de fertilização em ambos os casos. O nosso trabalho realça a importância da avaliação dos espermatozoides por um embriologista experiente como um dos passos fundamentais na abordagem destes casais.
ABSTRACT
Primary ciliary dyskinesia (PCD) is an inherited disease characterized by anomalies in the ciliary structure or function causing congenital impairment of mucociliary clearance. Kartagener syndrome (KS) is a rare subtype of PCD defined by the triad: bronchiectasis, chronic sinusitis and situs inversus. KS has an estimated prevalence of 1 in 20.000-40.000 and inheritance is usually autosomal recessive. Male patients with KS have almost no spontaneous pregnancies due to complete immotility of their spermatozoa. Intracytoplasmic sperm injection (ICSI) is considered the treatment of choice despite showing lower fertilization rates in these patients. Different tests for assortment and selection of viable immotile spermatozoa are described. We present two cases of Kartagener syndrome where pregnancy was achieved with ICSI using different methods of spermatozoa selection.
A Discinesia Ciliar Primária (DCP) é uma doença hereditária caracterizada por anomalias na estrutura ou função dos cílios levando a alterações na clearance mucociliar. A Síndrome de Kartagener (SK) é um subtipo raro de DCP definida pela tríade: bronquiectasias, sinusite crónica e situs inversus. A SK tem uma prevalência estimada de 1 em 20.000-40.000 e na maioria das vezes apresenta um padrão hereditário autossómico recessivo. Homens com SK apresentam uma probabilidade de gravidez espontânea quase nula devido à imobilidade dos espermatozoides. A injeção intracitoplasmática de espermatozoides (ICSI) é considerada o tratamento de escolha nestes casais, apesar de apresentar taxas de fertilização menor nestes pacientes. Diferentes testes para avaliação e seleção de espermatozoides imóveis viáveis são descritos. Apresentamos dois casos de SK em que a gravidez foi conseguida com ICSI usando diferentes métodos de seleção de espermatozoides.
KEYWORDS
Reproductive Techniques, Assisted; Kartagener Syndrome; Sperm Injections, Intracytoplasmic; Ciliary Motility Disorders; Asthenozoospermia.
Técnicas de reprodução assistida; Síndrome Kartagener; Injeção Intracitoplasmática de Espermatozóides; Anomalia motilidade ciliar; Astenozoospermia.
DISCLOSURES
The author certifies that there is no actual or potential conflict of interest in relation to this publication.
REFERENCES
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